中国组织工程研究

中国组织工程研究 ›› 2012, Vol. 16 ›› Issue (50): 9485-9490.doi: 10.3969/j.issn.2095-4344.2012.50.031

• 组织构建学术探讨 tissue construction academic discussion • 上一篇    下一篇

Smads介导转化生长因子β1信号转导通路与病理性瘢痕

潘 丽1，张选奋2   

  • 出版日期:2012-12-09 发布日期:2012-12-09

Transforming growth factor beta 1/Smads signal transduction and its relationship with scar formation

Pan Li1, Zhang Xuan-fen2   

  • Online:2012-12-09 Published:2012-12-09

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摘要：

背景：有研究表明转化生长因子β1既能促进创伤愈合又是刺激瘢痕增生的主要生长因子，而转化生长因子β1及其胞内转化生长因子β1/Smads信号转导途径与瘢痕形成存在重要关系。
目的：通过研究瘢痕形成过程中转化生长因子β1/Smads信号转导途径进一步探讨瘢痕发生的分子机制。
方法：以“瘢痕、转化生长因子β1、Smad蛋白”为关键词通过计算机检索分别检索CNKI数据库(http://epub.cnki.net/grid2008/index/ZKCALD.htm)；维普数据库(http://www.cqvip.com/)；Pubmed数据库(http://www.ncbi.nlm.nih.gov/pubmed/)，选择1995年10月至2011年10月相关文献，筛选出主要论述瘢痕形成及转化生长因子β1/Smads信号转导通路并于近期发表在国内外权威期刊的相关文章。
结果与结论：共纳入相关文献27篇，经整理分析后认为转化生长因子β1/Smads信号转导通路参与瘢痕形成，通过干预该途径的各环节可导致病理性瘢痕的发生。信号转导是转化生长因子β1发挥生物学功能的基本途径，所以更加深入研究转化生长因子β1信号转导及其调节可进一步补充瘢痕发生机制，以此为理论基础有利于应用生物工程等先进手段从分子水平干预瘢痕形成过程，使细胞能适时适度增殖、分化、凋亡及发挥功能，使创伤愈合更加理想。

Abstract:

BACKGROUND: Studies have shown that transforming growth factor beta 1 (TGF-β1) can promote wound healing and it is also an important growth factor to stimulate scar formation. TGF-β1 and TGF-β1/Smads signal transduction pathway have a significant relationship with scar formation.
OBJECTIVE: To further explore the molecular mechanisms of scar formation by studying TGF-β1/Smads signal transduction pathway in the scar formation process.
METHODS: By searching CNKI, VIP and PubMed in 1995-10/2010-10 using keywords of “scar, transforming growth factor β1, Smad”, we screened papers focusing on scar formation and TGF-β1/Smads signal transduction pathway that published recently in authoritative journals at home and abroad.
RESULTS AND CONCLUSION: Totally 27 relevant papers were included. These studies have shown that TGF-β1/Smads signal transduction pathway is involved in scar formation, and the occurrence of pathological scar can be lead through the various aspects of intervention in the way. TGF-β1 can play its basic biological functions via signal transduction. Therefore, the in-depth study of TGF-β1 signal transduction pathway and its controlling can further explore mechanisms of scar formation. Based on the above findings, it is beneficial for intervention of scar formation using biological engineering technology at the molecular level so that the cells can timely appear with proliferation, differentiation, and apoptosis, playing their functions. Finally, the wound healing becomes more ideal.